Sonogashira cross-coupling reaction of 3-iodoindazoles with various terminal alkynes: a mild and flexible strategy to design 2-aza tryptamines

✍ Scribed by Anca Arnautu; Valérie Collot; Javier Calvo Ros; Carole Alayrac; Bernhard Witulski; Sylvain Rault

• Book ID: 104250816
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 195 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)00393-3

✦ Synopsis

This paper describes a Sonogashira-type cross-coupling reaction of 3-iodoindazoles with various terminal alkynes as a general route to 3-alkynylindazoles. The coupling reaction is illustrated by the preparation of new indazolylpropiolic or propargylic derivatives. Scope and limitation of the method are outlined.