𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Unexpected aspartimide formation during coupling reactions using Asp(OAl) in solid-phase peptide synthesis

✍ Scribed by Sandra C. Vigil-Cruz; Jane V. Aldrich; Sandra C. Vigil-Cruz


Book ID
110269178
Publisher
Springer Netherlands
Year
1999
Tongue
English
Weight
41 KB
Volume
6
Category
Article
ISSN
1573-3149

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Problem of aspartimide formation in Fmoc
✍ JarosŁaw Ruczyński; Brygida Lewandowska; Piotr Mucha; Piotr Rekowski 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 132 KB

## Abstract The sequence‐dependent, acid‐ or base‐catalysed aspartimide formation is one of the most serious side reactions in solid‐phase synthesis of peptides containing aspartic acid. In the present work, we investigated the susceptibility of 4‐{__N__‐[1‐(4,4‐dimethyl‐2,6‐dioxocyclohexylidene)‐3

Use of Alloc-amino acids in solid-phase
✍ Nathalie Thieriet; Jordi Alsina; Ernest Giralt; François Guibé; Fernando Alberic 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 286 KB

The use of Alloc group in SPPS for the N t~ protection of amino acids is an alternative to the Boc and Fmoc protecting groups. The smooth removal of Alloc group in neutral conditions with catalytic amounts of Pd(PPh3)4 in the presence of PhSiH3 as a scavenger for the allyl system permits orthogonali

A new micro-test for the detection of in
✍ W.S. Hancock; J.E. Battersby 📂 Article 📅 1976 🏛 Elsevier Science 🌐 English ⚖ 292 KB

A rapid micro-test using 2,4,6-trinitrobenzenesulphonic acid has been developed to detect incomplete coupling reactions in solid phase peptide synthesis. This new test will detect 3 nmol of free amino groups per milligram of resin.

New anchors useful in solid phase peptid
✍ Jean-Claude Alfred; Jean-Louis Aubagnac; Monique Calmes; Jacques Daunis; Btissan 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 486 KB

A potyacrytIc resin oith NH2 funcffon8 uas made to react with o-bromoacetfc anhydrides with the viw of ffndfng new anchor8 use&Z In aottd phase peptide synthesis. Besides the normat aufde product, the process vfth Cz -bromopropfonic acfd anhydrfde gave rise to a d-akmtne derivattve whose structure w