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Understanding the molecular mechanism of platinum antitumor complexes containing aminophosphonic ligands.

✍ Scribed by M.J. Bloemink; J.P. Dorenbos; B.K. Keppler; J. Reedijk; H. Zahn

Book ID
103569541
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
62 KB
Volume
51
Category
Article
ISSN
0162-0134

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The presence of Ca 2+ has a marked effect on the reaction release of the phosphonate ligand as observed by NMR is significantly accelerated by the presence of Ca 2+ , which is kinetics of platinum phosphonate complexes with d(GpG). Compounds studied are [cis-Pt(NH 3 ) 2 (bmpaa)] and [Pt(R,S-ascribed