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Understanding the interactions between artemisinin and cyclodextrins: spectroscopic studies and molecular modeling

✍ Scribed by Hermine Zime-Diawara, Georges Dive, Géraldine Piel, Mansourou Moudachirou, Michel Frederich, Joëlle Quetin-Leclercq, Brigitte Evrard

Book ID
118801191
Publisher
Springer Netherlands
Year
2012
Tongue
English
Weight
572 KB
Volume
74
Category
Article
ISSN
0923-0750

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Hydroxypropyl-beta-cyclodextrin (HPBCD) was investigated as a possible solubilizer for a series of poorly water-soluble antimalarial drugs. The solubilities of artemisinin, artether, dihydroartemisinin, and 10-deoxoartemisinin in HPBCD solutions were studied. The phase-solubility profile of these dr