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Understanding Ribonucleotide Reductase Inactivation by Gemcitabine

✍ Scribed by Nuno M. F. S. A. Cerqueira; Pedro A. Fernandes; Maria J. Ramos

Book ID
102793750
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
515 KB
Volume
13
Category
Article
ISSN
0947-6539

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## Abstract Gemcitabine (2′,2′‐difluoro‐2′‐deoxycytidine, dFdC) is a very promising anticancer drug, already approved for clinical use in three therapeutic indications. It is metabolized intracellularly to 5′‐diphosphate (dFdCDP), which is known to be a potent inhibitor of ribonucleotide reductase

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## Abstract This article focuses on the first step of the catalytic mechanism for the reduction of ribonucleotides catalyzed by the enzyme Ribonucleotide Reductase (RNR). This corresponds to the activation of the substrate. In this work a large model of the active site region involving 130 atoms wa