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Inactivation of ribonucleotide reductase by nitric oxide

โœ Scribed by Michel Lepoivre; Franck Fieschi; Jacques Coves; Lars Thelander; Marc Fontecave

Book ID
115764257
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
470 KB
Volume
179
Category
Article
ISSN
0006-291X

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๐Ÿ“œ SIMILAR VOLUMES

Mechanism for ribonucleotide reductase i
Mechanism for ribonucleotide reductase inactivation by the anticancer drug gemcitabine
โœ Susana Pereira; Pedro Alexandrino Fernandes; Maria Joรฃo Ramos ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 147 KB

## Abstract Gemcitabine (2โ€ฒ,2โ€ฒโ€difluoroโ€2โ€ฒโ€deoxycytidine, dFdC) is a very promising anticancer drug, already approved for clinical use in three therapeutic indications. It is metabolized intracellularly to 5โ€ฒโ€diphosphate (dFdCDP), which is known to be a potent inhibitor of ribonucleotide reductase