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Underexpression of Cyclin-Dependent Kinase (CDK) Inhibitors in Cervical Carcinoma

โœ Scribed by Young Tae Kim; Nam Hoon Cho; Sang Won Park; Jae Wook Kim


Book ID
112247480
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
729 KB
Volume
71
Category
Article
ISSN
0090-8258

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A flexible six-step synthesis of potential cyclin-dependent kinase 2 (CDK2) inhibitors is reported. The synthesis involves the condensation between 3-chloro-4,4-dimethoxy-2-butanone and amidines, which provides acetyl-imidazoles and late stage palladium-catalyzed N-arylation to give the target pyrim