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Concise, flexible syntheses of 4-(4-imidazolyl)pyrimidine cyclin-dependent kinase 2 (CDK2) inhibitors

✍ Scribed by Mathieu Toumi; Marion Barbazanges; Sebastian H.B. Kroll; Hetal Patel; Simak Ali; R. Charles Coombes; Anthony G.M. Barrett

Book ID: 104098355
Publisher: Elsevier Science
Year: 2010
Tongue: French
Weight: 621 KB
Volume: 51
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2010.09.074

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✦ Synopsis

A flexible six-step synthesis of potential cyclin-dependent kinase 2 (CDK2) inhibitors is reported. The synthesis involves the condensation between 3-chloro-4,4-dimethoxy-2-butanone and amidines, which provides acetyl-imidazoles and late stage palladium-catalyzed N-arylation to give the target pyrimidine derivatives.

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