Carbon-14 radiosynthesis of 4-(5-chloro-
✍
Sean L. Kitson; Stuart Jones; William Watters; Fiona Chan; David Madge
📂
Article
📅
2010
🏛
John Wiley and Sons
🌐
French
⚖ 176 KB
## Abstract A method has been developed for the carbon‐14 radiosynthesis of [^14^C]XEN‐D0401, a 4‐(2‐hydroxyphenyl)quinolin‐2(1__H__)‐one derivative. The radiosynthetic route involves a series of __ortho__‐lithiations directed by both 2‐methoxymethyl (MOM) and pivaloyl protecting groups. This is de