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Uncompetitive inhibition of [3H]1,3-di-o-tolyl-guanidine-defined σ binding sites by desipramine, propranolol and alprenolol in rat brain

✍ Scribed by Yukihiko Shirayama; Kiyohisa Takahashi; Toru Nishikawa

Book ID: 119413912
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 162 KB
Volume: 331
Category: Article
ISSN: 0014-2999
DOI: 10.1016/s0014-2999(97)01051-0

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## Abstract The aim of the present study was to find out if a cell line of glial origin possesses sigma and/or phencyclidine (PCP) binding sites. Binding of [^3^H]1,3‐di‐o‐tolyl‐guanidine (DTG), a highly selective ligand for sigma binding sites, and of [^3^H]N‐[1‐(2‐thienyl)cyclohexyl] piperidine (