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Uncatalyzed microwave deuterium exchange labeling of bleomycin A2

✍ Scribed by Steve A. de Keczer; Tim S. Lane; Mohammad R. Masjedizadeh

Book ID
102374182
Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
100 KB
Volume
47
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Bleomycin sulfate in D~2~O was deuterated using microwave irradiation under catalyst free conditions. Following the removal of labile deuterium and purification, bleomycin A~2~ with mass M + 1 to M + 7 was obtained. Successful selective uncatalyzed microwave deuterium exchange reactions on examples from the following classes of heterocycles are also described: imidazole, thiazole, indole, purine, and quinazoline. The described method was used as a test for non‐labile active protons. Copyright © 2004 John Wiley & Sons, Ltd.

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