Unbalanced translocation t(1;3)(p12–13;q11) in meningiomas as the unique feature of chordoid differentiation

✍ Scribed by Heike Steilen-Gimbel; Isolde Niedermayer; Wolfgang Feiden; Arno Freiler; Wolf-Ingo Steudel; Klaus D. Zang; Wolfram Henn

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 160 KB
• Volume: 26
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/(sici)1098-2264(199911)26:3<270::aid-gcc14>3.0.co;2-w

✦ Synopsis

Chordoid meningioma is a rare histological subtype of meningiomas. Cytogenetic analysis of three cases revealed the unique feature of an unbalanced translocation der(1)t(1;3)(p12-13;q11) that was ascertained by chromosome microdissection and reverse fluorescence in situ hybridization. As the t(1;3) has not been observed in other subtypes of meningioma, it may represent a specific cytogenetic marker of chordoid meningiomas. It is not yet clear whether a fusion gene or the combined loss of genes from chromosome arms 1p and 3p is the pathogenetically important outcome of the translocation.