## Abstract Constitutive activation of tyrosine kinases as a consequence of chromosomal translocations, forming fusion genes, plays an important role in the development of hematologic malignancies, in particular, myeloproliferative syndromes (MPSs). In this respect, the t(9;22)(q34;q11) that result
Fusion of theEWS1 andWT1 genes as a result of the t(11;22)(p13;q12) translocation in desmoplastic small round cell tumors
โ Scribed by Benjamin, Laura E.; Fredericks, William J.; Barr, Frederic G.; Rauscher, Frank J.
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 536 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0098-1532
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The ETV6 gene is a member of the ETS family of transcription factors and the main target of chromosomal rearrangements affecting chromosome band 12p13. To date, more than 15 fusion partners of ETV6 have been characterized at the molecular level. Most of these fusions encode chimeric proteins with on
## Abstract Chronic myeloid leukemia (CML) is characterized by the presence of a t(9;22)(q34;q11.2), which leads to the wellโknown BCRโABL1 fusion protein. We describe a patient who was diagnosed clinically with a typical CML but on cytogenetic analysis was found to have a t(9;22)(p24;q11.2). Chrom