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Umpolung Reactivity of Difluoroenol Silyl Ethers with Amines and Amino Alcohols. Application to the Synthesis of Enantiopure α-Difluoromethyl Amines and Amino Acids

✍ Scribed by Huguenot, Florent; Billac, Anne; Brigaud, Thierry; Portella, Charles


Book ID
118033857
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
126 KB
Volume
73
Category
Article
ISSN
0022-3263

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Asymmetric synthesis of α-substituted am
✍ Kolb, Michael ;Barth, Jacqueline 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 English ⚖ 1015 KB

## Abstract The asymmetric synthesis of α‐substituted α‐amino acids and propargylamines is described. As chiral auxiliary we used (__S__)‐(–)‐1‐dimethoxymethyl‐2‐methoxymethylpyrrolidine (SDMP, **1**). Treatment of the amino acids or amines with SDMP **1** afforded the corresponding amidines **C**,