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N-Substituted α-trifluoromethyl β-nitro amines in the synthesis of fluorine-containing 1,2-diamines, amino alcohols, and β-amino acids

✍ Scribed by V. Yu. Korotaev; A. Yu. Barkov; M. I. Kodess; I. B. Kutyashev; P. A. Slepukhin; A. Ya. Zapevalov


Publisher
Springer
Year
2009
Tongue
English
Weight
603 KB
Volume
58
Category
Article
ISSN
1573-9171

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Lewis acid activation of chiral 2-triflu
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The reaction of chiral 2-trifluoromethyl-1,3-oxazolidines with various silylated nucleophiles under Lewis acid activation provides a stereoselective route to functionalized a-trifluoromethylamines. This methodology was successfully applied to the diastereoselective synthesis of trifluoromethylated h