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Ultraviolet mutagenesis and the SOS response in Escherichia coli: A personal perspective

✍ Scribed by Evelyn M. Witkin

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
551 KB
Volume
14
Category
Article
ISSN
0893-6692

No coin nor oath required. For personal study only.

✦ Synopsis

The study of ultraviolet (UV) mutagenesis in fscherichio coli began with the assumption that genes were likely to be changed at the instant of photon absorption. Over many decades, it became clear that postirradiation cellular activities, including enzymatic DNA repair of UV photo products and error-prone modes of tolerating unrepaired DNA lesions can exert profound influences on the mutagenic outcome of irradiation. Current study focusses on the molecular details of radiationinduced translesion DNA replication as the final event in UV mutagenesis.

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