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Ultraviolet-B–Induced Cyclobutane-pyrimidine Dimer Formation and Repair in Arctic Marine Macrophytes

✍ Scribed by Willem H. van de Poll; Dieter Hanelt; Kirsten Hoyer; Anita G. J. Buma; Anneke M. Breeman

Book ID
111836944
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
149 KB
Volume
76
Category
Article
ISSN
0031-8655

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The p53 tumor-suppressor gene has been implicated in the inducible activation of excision repair of ultraviolet (UV)-induced cyclobutane pyrimidine dimers (CPDs) in human cells. Because the large T antigen (LTAg) of the simian virus 40 (SV40) binds p53 protein and can interfere with its function, it