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Influence of cytosine methylation on ultraviolet-induced cyclobutane pyrimidine dimer formation in genomic DNA

✍ Scribed by Patrick J. Rochette; Sandrine Lacoste; Jean-Philippe Therrien; Nathalie Bastien; Douglas E. Brash; Régen Drouin

Book ID
113809288
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
528 KB
Volume
665
Category
Article
ISSN
0027-5107

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The p53 tumor-suppressor gene has been implicated in the inducible activation of excision repair of ultraviolet (UV)-induced cyclobutane pyrimidine dimers (CPDs) in human cells. Because the large T antigen (LTAg) of the simian virus 40 (SV40) binds p53 protein and can interfere with its function, it