Ultrastructural detection of cholesterol in the liver of alcoholic rats
โ Scribed by V. V. Ul'yanova; L. V. Molostova; A. S. Loginov
- Publisher
- Springer US
- Year
- 1990
- Tongue
- English
- Weight
- 814 KB
- Volume
- 109
- Category
- Article
- ISSN
- 0007-4888
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Ultrastructural identification of light microscopic giant mitochondria was performed on the same specimens for light and electron microscopic observations. The liver tissue specimens were fixed in OsO,, embedded in epoxy resin, cut 4 pm thick and stained with polychrome. At the beginning of the stud
## Abstract A single dose of 1 mg hydrocortisone per rat stimulates the incorporation of labeled acetate into the cholesterol of the liver by a factor of 2.7 measured 18 hours after the administration of the hormone and 2 hours after the tracer dose of labeled acetate.
Based on studies that show a role for the low-density lipoprotein (LDL)-receptor in arachidonic acid delivery and eicosanoid synthesis in macrophages, the present study investigated the effect of cholesterol supplementation on pathological changes and thromboxane (TX) synthesis in alcoholic liver in