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Ultrastructural and immunocytochemical localization of immunoglobulin synthesis in tumor cells in Hodgkin's disease

✍ Scribed by Prof. M. Reynès; V. Paczynski; M. Galtier; J. Diebold

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
987 KB
Volume
23
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

An immunocytochemical and uitrastructural study using the Fab fragment of an anti‐human Ig antibody labelled with peroxidase was carried out on affected lymph nodes from five Hodgkin's disease patients. The tumor cells (Reed‐Sternberg cells and Hodgkin cells) showed an exclusively hyaloplasmic granular staining. By comparing these grains with ribosome staining of the endoplasmic reticulum of plasma cells it could be suggested that they are free risobomes. This ribosomal Ig synthesis is a major argument for the B lymphocyte nature of Reed‐Sternberg and Hodgkin cells. The total absence of vacuole staining allows us to conclude that these cells are not histiocytic or macrophage derivatives.

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