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Clonal rearrangements of T-cell receptor and immunoglobulin genes and immunophenotypic antigen expression in different subclasses of Hodgkin's disease

✍ Scribed by Henrik Griesser; Alfred C. Feller; Tak W. Mak; Karl Lennert

Publisher: John Wiley and Sons
Year: 1987
Tongue: French
Weight: 775 KB
Volume: 40
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910400205

No coin nor oath required. For personal study only.

✦ Synopsis

Twenty-two cases of Hodgkin's disease (HD), representing the 4 different subclasses, were studied by immunophenotypic and immunogenotypic analysis. Quantitative immunophenotypic analysis o i HD infiltrates showed a predominance of CD3-positive T cells in all subtypes except the lymphocytic depletion (HDLD) subtype. Only 5 samples of HD [2 of lymphocytic predominance (HDLP), 2 of mixed cellularity (HDMC). and one of nodular sclerosis type (HDNS)] were found to have both their Ig and T-cell antigen receptor (TcR) genes in the germ-line configuration. The remaining patients with HDLP (3 cases), H D N S (5 cases), and H D M C (4 cases), all exhibited rearrangements of either TcRy or TCRy and TcRP genes, while all 5 cases of H D L D had either TCRy or immunoglobulin heavy-chain gene rearrangement. These results substantiate the view that Hodgkin's lymphomas contain clonal lymphocyte populations and that different rearrangement patterns may be associated with different subclasses of HD.

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