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Ultrastructural alterations in liver cells of humans, rats, and mouse hepatoma cells in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds

✍ Scribed by Arnold Schecter; Thomas A Gasiewicz; Howard Eisen; Fenton Schaffner


Book ID
119021719
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
1004 KB
Volume
14
Category
Article
ISSN
0045-6535

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## Abstract The administration of single oral doses of 200 ΞΌg kg^βˆ’1^ of 2,3,7,8‐tetrachlorodibenzo‐__p__‐dioxin to females of the outbred, Lac: P strain of rat results in the formation of hepatic multinucleate cells by cell fusion. Liver cell plasma membranes isolated 6 or 11 days after dosing show