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Ultrastructural alterations and modifications of nuclear RNA of rat liver by the combined action of thioacetamide and aflatoxin

✍ Scribed by M. O. Reynier; C. Lafarge-Frayssinet; C. Frayssinet

Book ID
102863274
Publisher
John Wiley and Sons
Year
1975
Tongue
French
Weight
1009 KB
Volume
16
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

When aflatoxin is administered to thioacetamide‐treated rats, the synthesis of nuclear RNA not only stops but the RNA that had accumulated in the nuclei by thioacetamide action disappears, probably by degradation β€œin situ” as none appears in the cytoplasm. Morphologically, the lesions provoked by aflatoxin add to those caused by thioacetamide. In the gigantic nucleoli that develop upon exposure to thioacetamide, aflatoxin provokes atypical segregations that result in the formation of larger and larger spaces in the nucleoli.

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The reversibility of inhibition of RNA a
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✍ C. Lafarge; C. Frayssinet πŸ“‚ Article πŸ“… 1970 πŸ› John Wiley and Sons 🌐 French βš– 817 KB

## Abstract Aflatoxin is a potent hepatocarcinogen. Biochemically the short‐term action which seems to be the most important is an inhibition of nucleic acid synthesis. Injection of low doses (from 500 to 1,000 ΞΌg/kg) made it possible to modulate the different inhibitions induced by aflatoxin. The