Ultrasound in organic synthesis 10 selec
Ultrasound in organic synthesis 10 selective ortho-lithiation of the bouveault reaction intermediate
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J. Einhorn; J.L. Luche
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Article
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1986
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Elsevier Science
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French
β 215 KB
The Bouveault reaction intermediate prepared under sonochemical conditions eat;lly undergoes orthodirected lithiation. The use of tetrahydropyran as a solvent dramatlcdlly ~11creases the rates and yields of metallation which can be accomplished with an in situ generated alkyl-lithium.