Ultrasound and microwave assisted synthesis of isoindolo-1,2-diazine: A comparative study
β Scribed by Vasilichia Bejan; Dorina Mantu; Ionel I. Mangalagiu
- Book ID
- 118502760
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 226 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1350-4177
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## Abstract Attracted by the possibility to optimize time and yield of the synthesis of difficult peptide sequences by MW irradiation, we compared Fmoc/tBu MWβassisted SPPS of 1β34 __N__βterminal fragment of parathyroid hormoneβrelated peptide (PTHrP) with its conventional SPPS carried out at RT. M
## Abstract The synthesis of isoindolo[2,1β__b__]pyrrolo[1,2β__d__][2,4]benzodiazocine 7 and isoindolo[1,2β__d__]pyrrolo[1,2β__a__]β[1,5]benzodiazocine 13 are described starting from 2β(2βmethoxycarbonyl)benzylphthalimide 1a and ethyl Ξ±βbromohomophthalate 9 respectively.