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UHRF1 Plays a Role in Maintaining DNA Methylation in Mammalian Cells

✍ Scribed by Bostick, M.; Kim, J. K.; Esteve, P.-O.; Clark, A.; Pradhan, S.; Jacobsen, S. E.

Book ID: 125811267
Publisher: American Association for the Advancement of Science
Year: 2007
Tongue: English
Weight: 581 KB
Volume: 317
Category: Article
ISSN: 0036-8075
DOI: 10.1126/science.1147939

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## Abstract It has been reported that genomic DNA methylation decreases gradually during cell culture and an organism's aging. However, less is known about the methylation changes of age‐related specific genes in aging. p21^Waf1/Cip1^ and p16^INK4a^ are cyclin‐dependent kinase (Cdk) inhibitors that