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UGT1A1 gene variations and irinotecan treatment in patients with metastatic colorectal cancer

✍ Scribed by Marcuello, E; Altés, A; Menoyo, A; del Rio, E; Gómez-Pardo, M; Baiget, M


Book ID
109998202
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
113 KB
Volume
91
Category
Article
ISSN
0007-0920

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## Abstract ## BACKGROUND It is known that the uridine‐diphosphoglucuronosyl transferase 1A1 (UGT1A1)\*28 polymorphism reduces UGT1A1 enzyme activity, which may lead to severe toxicities in patients who receive irinotecan. This study was conducted to assess the influence of this polymorphism on th