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The Role of UGT1A1*28 Polymorphism in the Pharmacodynamics and Pharmacokinetics of Irinotecan in Patients With Metastatic Colorectal Cancer

✍ Scribed by Toffoli, G.

Book ID: 111966200
Publisher: American Society of Clinical Oncology
Year: 2006
Tongue: English
Weight: 104 KB
Volume: 24
Category: Article
ISSN: 0732-183X
DOI: 10.1200/jco.2005.05.5400

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## Abstract ## BACKGROUND It is known that the uridine‐diphosphoglucuronosyl transferase 1A1 (UGT1A1)\*28 polymorphism reduces UGT1A1 enzyme activity, which may lead to severe toxicities in patients who receive irinotecan. This study was conducted to assess the influence of this polymorphism on th