Ubiquitin-like proteins in halobacteria
β Scribed by Debora Nercessian; Rosana Esther de Castro; Danilo Conde
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 122 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0233-111X
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## Abstract Ubiquitin and ubiquitinβlike proteins are known to be covalently conjugated to a variety of cellular substrates via a threeβstep enzymatic pathway. These modifications lead to the degradation of substrates or change its functional status. The ubiquitinβactivating enzyme (E1) plays a key
The data available at present indicates there are three distinct functions of ubiquitin, two of which are related to protein conjugation. The first of these has been extensively studied by our laboratory and others interested in nucleosomes and changes in chromatin states. The ubiquitin-histone (Ub-