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Ubiquitin-Dependent Pathway is Up-Regulated in Differentiating Lens Cells

✍ Scribed by FU SHANG; XIN GONG; JOHN W. McAVOY; CORAL CHAMBERLAIN; THOMAS R. NOWELL; Jr; ALLEN TAYLOR


Book ID
115605329
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
432 KB
Volume
68
Category
Article
ISSN
0014-4835

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## Abstract **Background:** Recent work has demonstrated the role of cdc kinase subunit 1 (Cks1) in the ubiquitin‐proteasome dependent degradation of CDK inhibitor p27^__Kip1__^ protein as an essential cofactor for SCF^Skp2^ ubiquitin ligase. Although over‐expression of Cks1 protein as well as it o