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Regulation of the ubiquitin proteasome pathway in human lens epithelial cells during the cell cycle

✍ Scribed by Qing Liu; Fu Shang; Weimin Guo; Marisa Hobbs; Paloma Valverde; Venkat Reddy; Allen Taylor

Book ID: 116455925
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 340 KB
Volume: 78
Category: Article
ISSN: 0014-4835
DOI: 10.1016/j.exer.2003.11.009

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## Abstract **Background:** Recent work has demonstrated the role of cdc kinase subunit 1 (Cks1) in the ubiquitin‐proteasome dependent degradation of CDK inhibitor p27^__Kip1__^ protein as an essential cofactor for SCF^Skp2^ ubiquitin ligase. Although over‐expression of Cks1 protein as well as it o