U50,488, a κ opioid receptor agonist, attenuates cocaine-induced increases in extracellular dopamine in the nucleus accumbens of rats
✍ Scribed by Maisonneuve, I.M.; Archer, S.; Glick, S.D.
- Book ID
- 122372497
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 370 KB
- Volume
- 181
- Category
- Article
- ISSN
- 0304-3940
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📜 SIMILAR VOLUMES
Reinforcing properties of drugs of abuse are reduced by the coadministration of kappa opioid receptor (KOR) agonists. This effect is related to the inhibition of dopamine (DA) release in the nucleus accumbens (NAc) produced by the acute administration of KOR agonists. The present study was undertake
## Opioid receptor agonists (e.g.,488) increase the locomotor activity of preweanling rats, while the same drugs depress the locomotor activity of adults. Curiously, direct stimulation of dopamine (DA) D 2 -like receptors fully attenuates the U-50,488-induced locomotor activity of preweanling rats