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Tyrosine phosphatases Shp1 and Shp2 have unique and opposing roles in oligodendrocyte development

โœ Scribed by Emory Kuo; Daniel K. Park; Iva D. Tzvetanova; Cindy V. Leiton; Brian S. Cho; Holly Colognato

Book ID
111183871
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
701 KB
Volume
113
Category
Article
ISSN
0022-3042

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Previous studies in this laboratory have shown that the SH-2 domaincontaining protein tyrosine phosphatase SHP-1 is expressed in CNS glia and functions to modulate cytokine activities in these cells. The present study demonstrates that SHP-1 is expressed within multiple regions of the CNS in vivo, e