𝔖 Bobbio Scriptorium
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Tyrosine kinase inhibitors and Ca2+ signaling: direct interactions with fura-2

✍ Scribed by Alf Berts; Kenneth P Minneman


Book ID
114017773
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
200 KB
Volume
389
Category
Article
ISSN
0014-2999

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Proteins with SH2 or phosphotyrosine binding (PTB) domains bind activated tyrosine kinase receptors and their substrates to propagate signals into cells. Both of the domains recognize phosphotyrosine. Selectivity in these interactions is conferred by short flanking peptide motifs. Therefore, potenti