𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Tyrosine hydroxylation in the rat striatum after fentanyl and droperidol in vivo

✍ Scribed by E. Freye

Publisher
Springer-Verlag
Year
1976
Tongue
English
Weight
246 KB
Volume
26
Category
Article
ISSN
0014-4819

No coin nor oath required. For personal study only.

✦ Synopsis

The effects of fentanyl, droperidol, and morphine on tyrosine hydroxylation in the rat striatum was measured after inhibition of aromatic amino acid decarboxylase with R04-4602. Any direct change in the product of hydroxylation (i.e.dopa) was supposed to reflect a change in enzyme activity. Fentanyl (0.1 mg/kg intraperitoneally) first (10 min) appears to slightly depress, and later (30 min) significantly activate tyrosine hydroxylation. Morphine (10 mg/kg i.p.) activates tyrosine hydroxylation to a much lesser degree than fentanyl. Droperidol (3 mg/kg i.p.) only slightly activates the in vivo activity of the enzyme.

πŸ“œ SIMILAR VOLUMES

GABA depolarizes neurons in the rat stri
GABA depolarizes neurons in the rat striatum: An in vivo study
✍ Nicola Biagio Mercuri; Paolo Calabresi; Alessandro Stefani; Francesca Stratta; G πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 293 KB

GABA, applied by iontophoresis to striatal neurons of the rat in an in vivo preparation, depolarized the membrane potential and decreased the input resistance in a dose-dependent manner. The null potential of the GABA depolarization was about -50 mV. In addition, a fading of the GABA-induced respons

Dopamine-somatostatin interactions in th
Dopamine-somatostatin interactions in the rat striatum: An in vivo microdialysis study
✍ Kyriaki Thermos; James Radke; Andreas Kastellakis; Yannis Anagnostakis; Christin πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 774 KB

Dopamine-somatostatin interactions were investigated in the rat striatum using in vivo microdialysis. Somatostatin-14 and somatostatin-28 M) were infused, and the levels of dopamine and its metabolites DOPAC and HVA were assessed using high pressure liquid chromatography with electrochemical detecti