GABA depolarizes neurons in the rat striatum: An in vivo study

✍ Scribed by Nicola Biagio Mercuri; Paolo Calabresi; Alessandro Stefani; Francesca Stratta; Giorgio Bernardi

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 293 KB
• Volume: 8
• Category: Article
• ISSN: 0887-4476
• DOI: 10.1002/syn.890080106

✦ Synopsis

GABA, applied by iontophoresis to striatal neurons of the rat in an in vivo preparation, depolarized the membrane potential and decreased the input resistance in a dose-dependent manner. The null potential of the GABA depolarization was about -50 mV. In addition, a fading of the GABA-induced response was observed for prolonged and relatively high amino acid application. We conclude that GABA has a depolarizing effect on striatal cells. This is in line with recent in vitro works describing a depolarizing effect of GABA in the rat neostriatum.