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Tyrosine-317 of p52Shc mediates androgen-stimulated proliferation signals in human prostate cancer cells

โœ Scribed by Lee, Ming-Shyue; Igawa, Tsukasa; Lin, Ming-Fong


Book ID
110068528
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
270 KB
Volume
23
Category
Article
ISSN
0950-9232

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โœ Lifang Lu; Holger Schulz; Dieter A Wolf ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› BioMed Central ๐ŸŒ English โš– 756 KB

## Background: The cyclin-dependent kinase inhibitor p27 is a putative tumor suppressor that is downregulated in the majority of human prostate cancers. the mechanism of p27 down-regulation in prostate cancers in unknown, but presumably involves increased proteolysis mediated by the scfskp2 ubiquit