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Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum

✍ Scribed by Akira Futatsugi; Etsuko Ebisui; Katsuhiko Mikoshiba


Book ID
111180729
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
875 KB
Volume
105
Category
Article
ISSN
0022-3042

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The functional significance of the 2- and 3-hydroxyl groups of 1 D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] was probed by using Ins(1,4,5)P3 analogues variously modified at positions 2 and 3 or elsewhere. The intrinsic activities of these compounds were compared to that of Ins(1,4,5)P3, using