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Type 1 and Type 2 5α-Reductase Expression in the Development and Progression of Prostate Cancer

✍ Scribed by Lynn N. Thomas; Robert C. Douglas; Catherine B. Lazier; Catherine K.L. Too; Roger S. Rittmaster; Donald J. Tindall

Book ID
113610388
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
490 KB
Volume
53
Category
Article
ISSN
0302-2838

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## Abstract In the prostate, the enzyme encoded by the __SRD5A2__ gene (5α‐reductase) converts testosterone to dihydrotestosterone, a potent androgen that has been hypothesized to play a role in the genesis of prostate cancer. Several polymorphisms have been identified in the __SRD5A2__ gene, inclu