Associations between polymorphisms in the steroid 5-α reductase type II (SRD5A2) gene and benign prostatic hyperplasia and prostate cancer☆
✍ Scribed by Muhammad T. Salam; Giske Ursin; Eila C. Skinner; Tesfaye Dessissa; Juergen K.V. Reichardt
- Book ID
- 116955716
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 118 KB
- Volume
- 23
- Category
- Article
- ISSN
- 1078-1439
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## Abstract In the prostate, the enzyme encoded by the __SRD5A2__ gene (5α‐reductase) converts testosterone to dihydrotestosterone, a potent androgen that has been hypothesized to play a role in the genesis of prostate cancer. Several polymorphisms have been identified in the __SRD5A2__ gene, inclu
## Abstract Controversy exists over the significance of associations between the __SRD5A2__ (5α‐reductase type 2) polymorphisms, A49T and V89L, and risk of prostate cancer. These potentially functional polymorphisms may alter life‐long exposure to androgens with subsequent effects on male health an