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Two-step syntheses of 3-methyl and 3-phenyl-1,2,4-benzotriazines

✍ Scribed by Mohamed Khodja; Saad Moulay; Hocine Boutoumi; Horst Wilde

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
121 KB
Volume
17
Category
Article
ISSN
1042-7163

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✦ Synopsis

3-Methyl-1,2,4-benzotriazine and some of its derivatives were prepared in moderate yields (50-70%) via a reductive cyclization by a PtO 2catalyzed hydrogenation of the corresponding 2nitrophenylhydrazones of the pyruvic acid. The latter compounds were obtained in yields higher than 90% by reacting 2-nitrophenylhydrazines with sodium pyruvate salt. Three 3-phenyl-1,2,4-benzotriazine compounds were also produced via a reductive cyclization by a Pt/C-catalyzed hydrogenation of their corresponding 2-nitrophenylhydrazono-ethers in high yields (>70%).

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