𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Two-Stage Designs for Gene–Disease Association Studies with Sample Size Constraints

✍ Scribed by Jaya M. Satagopan; E. S. Venkatraman; Colin B. Begg


Book ID
110725197
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
165 KB
Volume
60
Category
Article
ISSN
0006-341X

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Two-Stage sampling designs for gene asso
✍ Duncan Thomas; Rongrong Xie; Mulugeta Gebregziabher 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 211 KB 👁 2 views

## Abstract We consider two‐stage case‐control designs for testing associations between single nucleotide polymorphisms (SNPs) and disease, in which a subsample of subjects is used to select a panel of “tagging” SNPs that will be considered in the main study. We propose a pseudolikelihood [Pepe and

Including sampling and phenotyping costs
✍ Hans-Helge Müller; Roman Pahl; Helmut Schäfer 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 239 KB 👁 2 views

## Abstract We propose optimized two‐stage designs for genome‐wide case‐control association studies, using a hypothesis testing paradigm. To save genotyping costs, the complete marker set is genotyped in a sub‐sample only (stage I). On stage II, the most promising markers are then genotyped in the