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Sample-size properties of a case-control association analysis of multistage SNP studies for identifying disease susceptibility genes

✍ Scribed by Nobutaka Kitamura; Kouhei Akazawa; Shin-ichi Toyabe; Akinori Miyashita; Ryozo Kuwano; Junichiro Nakamura


Book ID
106252305
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
357 KB
Volume
53
Category
Article
ISSN
1435-232X

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## Abstract Alzheimer's disease (AD) is characterized by an extensive loss of cholinergic neurons, and their cortical projections, from the basal forebrain area. The resulting reduction in cholinergic activity is associated with decreased levels of the neurotransmitter acetylcholine (ACh), decrease