## Abstract The expression of nine oncogenes (cβmyc, Nβmyc, Nβras, Hβras, kβras, abl, fos, src, and raf) and two tumor suppressor genes (p53 and RB) were studied by northern blot hybridization in six human hepatocellular carcinoma or hepatoblastoma cell lines (PLC/PRF/5, HepSB, Hep G2, 2.2.15, HLE,
Two prostate carcinoma cell lines demonstrate abnormalities in tumor suppressor genes
β Scribed by Steven J. Rubin; Dennis E. Hallahan; Charles R. Ashman; David G. Brachman; Michael A. Beckett; Subbulakshmi Virudachalam; David W. Yandell; Ralph R. Weichselbaum
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 925 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0022-4790
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The above article, published online on 22 April 2008 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor in Chief, Prof. Peter Lichter, and John Wiley & Sons Ltd. The retraction has been agreed due to errors identified in Figs, 3,
In this study, we analyzed 10 human squamous cell carcinomas (SCCs) for alterations in the p53 tumor suppressor gene in exons 4 through 9 by single-strand conformation polymorphism (SSCP) analysis. We found that 2 of 10 SCCs displayed unusual SSCP alleles at exon 7 of the p53 gene. Subsequent clonin
Loss of heterozygosity at 4 tumor-suppressor gene loci (pS3, apc, mcc and Rb) was investigated using polymerase chain reactions, in 49 esophageal squamous-cell carcinoma specimens from patients who had undergone curative resection. Mutations in the p53 gene within exons 5 to 8 were also examined. LO
## Abstract To investigate the importance of oncogenes and tumor suppressor genes in bladder carcinogenesis, we determined the status of the expression of the __MDMβ2__ and __p53__ genes and genetic alterations in the __p53__ gene in five bladder carcinoma cell lines and one kidney urothelial carci