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Two novel translocations disrupt the RUNX1 gene in acute myeloid leukemia

✍ Scribed by Haiping Dai; Yongquan Xue; Jinlan Pan; Yafang Wu; Yong Wang; Juan Shen; Jun Zhang

Book ID
113513155
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
378 KB
Volume
177
Category
Article
ISSN
0165-4608

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Translocation t(8;21)(q22;q22) is a common karyotypic abnormality detected in about 15% of acute myeloid leukemia (AML) cases. The rearrangement results in fusion of the RUNX1 (also known as AML1) and CBFA2T1 (also known as ETO) genes, generating a 5'RUNX1/3'CBFA2T1 transcriptionally active fusion g