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Two novel mutations in the amyloid precursor protein (APP) gene

✍ Scribed by Fernandez-Novoa, Lucia; Mesa, Maria Dolores; Corzo, Lola; de Olano, Marta; Cacabelos, Ramon


Book ID
122637705
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
193 KB
Volume
21
Category
Article
ISSN
0197-4580

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A novel mutation, a C to T transition at base pair 2124 in exon 17 of the amyloid beta-protein precursor (APP) gene, has been identified by direct sequencing of amplified DNA from two Alzheimer's disease (AD) patients. A simple oligonucleotide-hybridization procedure was developed to allow populatio