Two new tumor-specific antigenic peptides encoded by gene MAGE-C2 and presented to cytolytic T lymphocytes by HLA-A2

✍ Scribed by Wenbin Ma; Catherine Germeau; Nathalie Vigneron; Anne-Sophie Maernoudt; Sandra Morel; Thierry Boon; Pierre G. Coulie; Benoît J. Van den Eynde

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: French
• Weight: 236 KB
• Volume: 109
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.20038

✦ Synopsis

Abstract

We have identified 2 antigens recognized by several melanoma‐specific cytolytic T lymphocyte clones isolated from a melanoma patient with a clinical history of tumor regression after immunotherapy. Both antigens are presented by HLA‐A2 and encoded by gene MAGE‐C2, a cancer‐germline gene shown previously to be silent in normal somatic tissues and expressed in 40% of melanomas and in other tumor types. One antigen corresponds to peptide ALKDVEERV~336–344~, whereas the other corresponds to peptide LLFGLALIEV~191–200~. The CTL clones recognizing these 2 peptides also recognized allogeneic tumor cell lines expressing MAGE‐C2 and HLA‐A2. These 2 new peptides are the first known MAGE‐C antigens and represent promising targets for cancer immunotherapy. © 2004 Wiley‐Liss, Inc.