Two New Resorcinol Derivatives with Strong Cytotoxicity from the Roots of Ardisia brevicaulisDiels

✍ Scribed by Li Bao; Manyuan Wang; Feng Zhao; Yisong Zhao; Hongwei Liu

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 149 KB
• Volume: 7
• Category: Article
• ISSN: 1612-1872
• DOI: 10.1002/cbdv.200900349

✦ Synopsis

Abstract

Two new resorcinol derivatives, 4‐hydroxy‐2‐methoxy‐6‐[(8__Z__)‐pentadec‐8‐en‐1‐yl]phenyl acetate (1) and 4‐hydroxy‐2‐methoxy‐6‐pentadecylphenyl acetate (2), together with known compounds ardisiphenol D (3), 5‐tridecylresorcinol (4), 5‐pentadecylresorcinol (5), 5‐[(8__Z__)‐pentadec‐8‐en‐1‐yl]resorcinol (6), belamcandaquinones C and D (7 and 8, resp.), ardisicrenoside A, ardisiacrispin B, (22__E__)‐24‐ethyl‐5__α__‐cholesta‐7,22‐dien‐3‐one, and (22__E__)‐24‐ethyl‐5__α__‐cholesta‐7,22‐dien‐3__β__‐ol were isolated from the MeOH extract of the roots of Ardisia brevicaulis Diels. Their structures were determined by spectroscopic analysis including ESI‐ and EI‐MS, and NMR data. Cytotoxicities of 1–4 against cell lines A549, MCF‐7, and PANC‐1 were tested in vitro by the MTT (=3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2__H__‐tetrazolium bromide) method. Compounds 1–4 showed cytotoxic activity against all cell lines stronger than that of cisplatin against A549.