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Two New Cytotoxic Biphenyls from the Roots of Incarvillea arguta

✍ Scribed by Jian-Jun Fu; Hui-Zi Jin; Yun-Heng Shen; Jiang-Jiang Qin; Yan Wang; Ying Huang; Qi Zeng; Shi-Kai Yan; Wei-Dong Zhang

Publisher
John Wiley and Sons
Year
2009
Tongue
German
Weight
159 KB
Volume
92
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

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Two novel biphenyls, named incargutines A (1) and B (2), were isolated from the roots of Incarvillea arguta, and the structures were elucidated by detailed spectroscopic analysis, including HR‐ESI‐MS data and 2D‐NMR spectroscopy. Compounds 1 and 2 contain an unprecedented C‐atom skeleton, namely a 4‐methylbiphenyl unit fused with a 7‐methylcyclopentane unit at C(2) and C(3) (i.e., a 1,7‐dimethyl‐4‐phenylindane skeleton). The cytotoxicity of 1 and 2 was evaluated with four tumor cell lines, A549, LOVO, CEM, and MDA‐MB‐435 (MDA), by an MTT assay.

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