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Two new polymorphic markers in the human proα2(1) collagen gene

✍ Scribed by Diana K. Brebner; Anne F. Grobler-Rabie; A. J. Bester; C. G. Mathew; C. D. Boyd

Publisher
Springer
Year
1985
Tongue
English
Weight
330 KB
Volume
70
Category
Article
ISSN
0340-6717

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✦ Synopsis

Structural defects in the human type 1 collagen genes are known to be the cause of several inherited disorders of connective tissue, such as osteogenesis imperfecta. The analysis and prenatal diagnosis of these disorders would be facilitated by establishing a set of polymorphic markers at these gene loci. We have previously reported the presence of an Msp 1 restriction fragment length polymorphism in the proct2 (1) collagen genes of several Southern African populations (Grobler-Rabie et al., in press). This report describes the detection of a Bgl II and an EcoRI polymorphism in the proa2 gene of South African Blacks.

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